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RING3, FSH

     
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Product Information
Primary Accession NM_001113182
Species Human
Sequence MHHHHHHEVS NPKKPGRVTN QLQYLHKVVM KALWKHQFAW PFRQPVDAVK LGLPDYHKII KQPMDMGTIK RRLENNYYWA ASECMQDFNT MFTNCYIYNK PTDDIVLMAQ TLEKIFLQKV ASMPQEEQEL VVTIPKNSHK KGAKLAALQG SVTSAHQVPA VSSVSHTALY TPPPEIPTTV LNIPHPSVIS SPLLKSLHSA GPPLLAVTAA PPAQPLAKKK GVKRKADTTT PTPTAILAPG SPASPPGSLE PKAARLPPMR RESGRPIKPP RKDLPDSQQQ HQSSKKGKLS EQLKHCNGIL KELLSKKHAA YAWPFYKPVD ASALGLHDYH DIIKHPMDLS TVKRKMENRD YRDAQEFAAD VRLMFSNCYK YNPPDHDVVA MARKLQDVFE FRYAKMPDEP LE
Purity > 95% by reducing SDS-PAGE.
Endotoxin Level < 1 EU/ µg, determined by LAL method.
Formulation Sterile liquid solution contains 25mM HEPES, pH7.5, 150mM NaCl, 5% glycerol, 0.5 mM TCEP. Frozen solution.
Additional Information
Target Background Bromodomain (BRD) is an extensive family of protein domains, originally identified in and named after the Drosophila protein Brahma. Members of BRD family share a conserved atypical left-handed four helix bundle structure, and specifically bind to ε-lysine acetylated proteins. It is well known that histone acetylation and methylation play a central role in epigenetics and are important for various gene transcription events, thus the acetyl-lysine binding property of BRDs make them suitable drug targets for epigenetics. Currently, there are 46 diverse human proteins containing 61 BRDs. These include histone acetyltransferases, ATP-dependent chromatin-remodeling complex proteins, and nuclear scaffold proteins. The main functions of BRDs in vivo include chromatin acetylation and deacetylation, nucleosome assembly and remodeling, and organizations of chromosome or chromatin domains.
Recombinant human BRD2 (65-459) with His tag produced in E. coli is a single, non-glycosylated polypeptide chain containing 402 amino acids. A fully biologically active molecule, BRD2 (65-459) has a molecular mass of 45.3 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at .
Protein Information
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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