癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
(DANRE) znf143 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q1LYE3 |
| Reactivity | Zebrafish |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Clone Names | RB46770 |
| Calculated MW | 67929 Da |
| Gene ID | 393954 |
|---|---|
| Other Names | Zinc finger protein 143, Selenocysteine tRNA gene transcription-activating factor, znf143, staf |
| Target/Specificity | This (DANRE) znf143 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 564-596 amino acids of DANRE znf143. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (DANRE) znf143 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | znf143b {ECO:0000303|PubMed:31969120} |
|---|---|
| Function | Transcription factor that activates expression of genes transcribed by both RNA polymerases II and III, and which is required to safeguard mitochondrial activity. Specifically recognizes and binds the Staf-binding site (SBS), a consensus DNA-binding motif present in thousands of promoters. Activates the gene for selenocysteine tRNA (tRNAsec). Activates expression of small nuclear RNA (snRNA) transcribed by RNA polymerases II and III. Also activates expression of mRNAs and acts as a key regulator of cell proliferation and differentiation by specifically activating expression of a subset of nuclear-encoded mitochondrial genes, thereby controlling mitochondrial function. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:O70230}. Chromosome {ECO:0000250|UniProtKB:O70230}. Note=Localizes to chromatin {ECO:0000250|UniProtKB:O70230} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the activator element (AE) motif of the selenocysteine tRNA gene promoter (By similarity).
REFERENCES
Myslinski E.,et al.Gene 330:149-158(2004).
Howe K.,et al.Nature 496:498-503(2013).
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¥ 699.00
Cat# Azb18703c
