癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
UBA6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | A0AVT1 |
| Other Accession | Q8C7R4 |
| Reactivity | Human, Mouse |
| Predicted | Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 117970 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 55236 |
|---|---|
| Antigen Region | 861-889 aa |
| Other Names | Ubiquitin-like modifier-activating enzyme 6, Ubiquitin-activating enzyme 6, Monocyte protein 4, MOP-4, Ubiquitin-activating enzyme E1-like protein 2, E1-L2, UBA6, MOP4, UBE1L2 |
| Dilution | WB~~0.25 |
| Target/Specificity | This UBA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-889 amino acids from the C-terminal region of human UBA6. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UBA6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBA6 |
|---|---|
| Synonyms | MOP4, UBE1L2 |
| Function | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. |
| Tissue Location | Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).
REFERENCES
Groettrup, M., et al. Trends Biochem. Sci. 33(5):230-237(2008)
Chiu, Y.H., et al. Mol. Cell 27(6):1014-1023(2007)
Pelzer, C., et al. J. Biol. Chem. 282(32):23010-23014(2007)
Jin, J., et al. Nature 447(7148):1135-1138(2007)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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