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GPR88 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | Q9GZN0 |
| Other Accession | Q9EPB7, Q9ESP4 |
| Reactivity | Human, Rat |
| Predicted | Dog, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40246 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 54112 |
|---|---|
| Antigen Region | 325-352 aa |
| Other Names | Probable G-protein coupled receptor 88, Striatum-specific G-protein coupled receptor, GPR88, STRG |
| Dilution | WB~~1:2000 |
| Target/Specificity | This GPR88 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-352 amino acids from the C-terminal region of human GPR88. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR88 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR88 |
|---|---|
| Synonyms | STRG |
| Function | Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (PubMed:35501348). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (PubMed:23936473). In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (PubMed:23936473). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9ESP4}; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q9ESP4}. Nucleus {ECO:0000250|UniProtKB:Q9ESP4}. Note=Localized to cilia in ciliated cells; whereas in non-ciliated cells, distributed throughout the cell membrane (PubMed:23936473). During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood {ECO:0000250|UniProtKB:Q9ESP4, ECO:0000269|PubMed:23936473} |
| Tissue Location | Expressed predominantly in the striatum. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GPR88 is an orphan receptor.
REFERENCES
Mizushima, K., et al. Genomics 69(3):314-321(2000)
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