ALDH2 Antibody

Affinity Purified Rabbit Polyclonal Antibody (Pab)

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Western blot analysis of lysates from HepG2,A549 cell line,mouse liver,mouse lung,rat liver tissue lysate(from left to right), using ALDH2 Antibody(Cat. #AW5333). AW5333 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
Formalin-fixed and paraffin-embedded human brain tissue reacted with ALDH2 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
ALDH2 Antibody (Cat. #AW5333) flow cytometry analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

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背景知识

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	FC, IHC-P, WB
Primary Accession	P05091
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Calculated MW	56381 Da
Isotype	Rabbit IgG
Antigen Source	HUMAN

Additional Information
Gene ID	217
Other Names	ALDH2; ALDM; Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI
Dilution	FC~~1:10~50 IHC-P~~1:100~500 WB~~1:1000
Target/Specificity	This ALDH2 antibody is generated from rabbits immunized with human ALDH2 recombinant protein.
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions	ALDH2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	ALDH2
Synonyms	ALDM
Function	Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
Cellular Location	Mitochondrion matrix.

Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

Western Blot Protocol

Blocking Peptides Protocol

Dot Blot Protocol

Immunohistochemistry Protocol

Immunofluorescence Protocol

Immunoprecipitation Protocol

Flow Cytomety Protocol

Cell Culture Protocol

BACKGROUND

ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme.

REFERENCES

Guo,Y.M., World J. Gastroenterol. 14 (9), 1444-1449 (2008)
Chen,L., PLoS Med. 5 (3), E52 (2008)
Teeguarden,J.G., Inhal Toxicol 20 (4), 375-390 (2008)
Yoshida,A., Pharmacogenetics 2 (4), 139-147 (1992)

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¥ 2,600.00

Cat# AW5333

Size:

100 µl

Price:

¥ 2,600.00

Quantity:

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Availability: In Stock

询价

ALDH2 Antibody

Affinity Purified Rabbit Polyclonal Antibody (Pab)

BACKGROUND

REFERENCES

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