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MCCC2 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - MCCC2 Antibody (Center) AW5273
    Western blot analysis of lysates from rat liver tissue and NCI-H292 cell line (from left to right), using MCCC2 Antibody (Center)(Cat. #AW5273). AW5273 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
  • 4 - MCCC2 Antibody (Center) AW5273
    Flow cytometric analysis of ATDC5 cells using MCCC2 Antibody (Center) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • 14 - MCCC2 Antibody (Center) AW5273
    Formalin-fixed and paraffin-embedded human hepatocarcinoma with MCCC2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, FC, WB
Primary Accession Q9HCC0
Reactivity Mouse, Rat, Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 61333 Da
Isotype Rabbit IgG
Antigen Source HUMAN
Additional Information
Gene ID 64087
Antigen Region 163-189 aa
Other Names MCCC2; MCCB; Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta
Dilution IHC-P~~1:100~500
FC~~1:10~50
WB~~ 1:1000
Target/Specificity This MCCC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-189 amino acids from the Central region of human MCCC2.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMCCC2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCCC2
Synonyms MCCB
Function Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.
Cellular Location Mitochondrion matrix
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

MCCC2 is the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA.

REFERENCES

Uematsu,M., et.al., J. Hum. Genet. 52 (12), 1040-1043 (2007)

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