UHRF1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant UHRF1.
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IHC, IF |
---|---|
Primary Accession | Q96T88 |
Other Accession | NM_013282 |
Reactivity | Human |
Host | Mouse |
Clonality | monoclonal |
Isotype | IgG1 Kappa |
Clone Names | 3A11 |
Calculated MW | 89814 Da |
Gene ID | 29128 |
---|---|
Other Names | E3 ubiquitin-protein ligase UHRF1, 632-, Inverted CCAAT box-binding protein of 90 kDa, Nuclear protein 95, Nuclear zinc finger protein Np95, HuNp95, hNp95, RING finger protein 106, Transcription factor ICBP90, Ubiquitin-like PHD and RING finger domain-containing protein 1, hUHRF1, Ubiquitin-like-containing PHD and RING finger domains protein 1, UHRF1, ICBP90, NP95, RNF106 |
Target/Specificity | UHRF1 (NP_037414, 694 a.a. ~ 793 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | UHRF1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
1.DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination.Du Z, Song J, Wang Y, Zhao Y, Guda K, Yang S, Kao HY, Xu Y, Willis J, Markowitz SD, Sedwick D, Ewing RM, Wang Z.Sci Signal. 2010 Nov 2;3(146):ra80.2.Interplay between Np95 and Eme1 in the DNA damage response.Mistry H, Gibson L, Yun JW, Sarras H, Tamblyn L, McPherson JP.Biochem Biophys Res Commun. 2008 Oct 24;375(3):321-5. Epub 2008 Aug 8.

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问,联系:0512-88856768 tech-china@abcepta.com.