癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SEMA7A Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SEMA7A.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O75326 |
| Other Accession | NM_003612 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3D3 |
| Calculated MW | 74824 Da |
| Gene ID | 8482 |
|---|---|
| Other Names | Semaphorin-7A, CDw108, JMH blood group antigen, John-Milton-Hargen human blood group Ag, Semaphorin-K1, Sema K1, Semaphorin-L, Sema L, CD108, SEMA7A, CD108, SEMAL |
| Target/Specificity | SEMA7A (NP_003603, 536 a.a. ~ 633 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SEMA7A Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.
REFERENCES
The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis. Lazova R, et al. Am J Dermatopathol, 2009 Apr. PMID 19318806.Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression. Scott GA, et al. J Invest Dermatol, 2009 Apr. PMID 18987670.Rapid detection of JMH antibodies with recombinant Sema7A (CD108) protein and the particle gel immunoassay. Seltsam A, et al. Transfusion, 2008 Jun. PMID 18422858.Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins. Scott GA, et al. J Invest Dermatol, 2008 Jan. PMID 17671519.Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. Kang HR, et al. J Exp Med, 2007 May 14. PMID 17485510.
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