癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SAA1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SAA1.
- 产品详情
- 文献引用 : 2
- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | P0DJI8 |
| Other Accession | BC007022 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b kappa |
| Clone Names | 3C11-2C1 |
| Calculated MW | 13546 Da |
| Gene ID | 6288 |
|---|---|
| Other Names | Serum amyloid A-1 protein, SAA, Amyloid protein A, Amyloid fibril protein AA, Serum amyloid protein A(2-104), Serum amyloid protein A(3-104), Serum amyloid protein A(2-103), Serum amyloid protein A(2-102), Serum amyloid protein A(4-101), SAA1 |
| Target/Specificity | SAA1 (AAH07022, 1 a.a. ~ 122 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SAA1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn s disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
REFERENCES
[Distribution of genetic polymorphisms of serum amyloid protein A1 in healthy Chinese Han and Uighur populations in Xinjiang.] Xie X, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2010 Aug. PMID 20677144.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Serum amyloid A is elevated in the serum of lung cancer patients with poor prognosis. Cho WC, et al. Br J Cancer, 2010 Jun 8. PMID 20502455.Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection. Kramer HB, et al. PLoS Pathog, 2010 May 6. PMID 20463814.Acute serum amyloid A induces migration, angiogenesis, and inflammation in synovial cells in vitro and in a human rheumatoid arthritis/SCID mouse chimera model. Connolly M, et al. J Immunol, 2010 Jun 1. PMID 20435930.
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