癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PEPD Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant PEPD.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, IP, E |
|---|---|
| Primary Accession | P12955 |
| Other Accession | BC015027 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1D5-H3 |
| Calculated MW | 54548 Da |
| Gene ID | 5184 |
|---|---|
| Other Names | Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Peptidase D, Proline dipeptidase, Prolidase, PEPD, PRD |
| Target/Specificity | PEPD (AAH15027, 1 a.a. ~ 493 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PEPD Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Dilatation of the ascending aorta is associated with low serum prolidase activity. Akcakoyun M, et al. Tohoku J Exp Med, 2010. PMID 20383038. Prolidase activity and oxidative status in patients with thalassemia major. Cakmak A, et al. J Clin Lab Anal, 2010. PMID 20087956. Serum prolidase activity and oxidative status in patients with stage I endometrial cancer. Arioz DT, et al. Int J Gynecol Cancer, 2009 Oct. PMID 19823062. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Takeuchi F, et al. Diabetes, 2009 Jul. PMID 19401414. Characterization of prolidase I and II purified from normal human erythrocytes: comparison with prolidase in erythrocytes from a patient with prolidase deficiency. Uramatsu S, et al. Amino Acids, 2009 Sep. PMID 19263194.
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