癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
P2RX5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant P2RX5.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q93086 |
| Other Accession | NM_002561 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1C5 |
| Calculated MW | 49303 Da |
| Gene ID | 5026 |
|---|---|
| Other Names | P2X purinoceptor 5, P2X5, ATP receptor, Purinergic receptor, P2RX5, P2X5 |
| Target/Specificity | P2RX5 (NP_002552, 126 a.a. ~ 224 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | P2RX5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene.
REFERENCES
Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform. Kotnis S, et al. Mol Pharmacol, 2010 Jun. PMID 20223879.Aberrant expression of the hematopoietic-restricted minor histocompatibility antigen LRH-1 on solid tumors results in efficient cytotoxic T cell-mediated lysis. Overes IM, et al. Cancer Immunol Immunother, 2009 Mar. PMID 18719914.Go it alone no more--P2X7 joins the society of heteromeric ATP-gated receptor channels. Dubyak GR. Mol Pharmacol, 2007 Dec. PMID 17895406.P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate. Duckwitz W, et al. J Biol Chem, 2006 Dec 22. PMID 17001079.Purinoceptor expression on keratinocytes reflects their function on the epidermis during chronic venous insufficiency. Metcalfe MJ, et al. Arch Dermatol Res, 2006 Nov. PMID 16967306.
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