癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MAF Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant MAF.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | O75444 |
| Other Accession | NM_005360 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 6B6 |
| Calculated MW | 38492 Da |
| Gene ID | 4094 |
|---|---|
| Other Names | Transcription factor Maf, Proto-oncogene c-Maf, V-maf musculoaponeurotic fibrosarcoma oncogene homolog, MAF |
| Target/Specificity | MAF (NP_005351, 304 a.a. ~ 403 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MAF Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families. Kim HN, et al. J Hum Genet, 2010 Jul 29. PMID 20668459.Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. Fontaine-Bisson B, et al. Diabetologia, 2010 Oct. PMID 20571754.SUMOylation attenuates c-Maf-dependent IL-4 expression. Lin BS, et al. Eur J Immunol, 2010 Apr. PMID 20127678.KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming. Hansen A, et al. Genes Dev, 2010 Jan 15. PMID 20080955.Transcriptional activation of human MMP-13 gene expression by c-Maf in osteoarthritic chondrocyte. Li T, et al. Connect Tissue Res, 2010. PMID 20067416.
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