癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LHX4 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant LHX4.
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC, E |
|---|---|
| Primary Accession | Q969G2 |
| Other Accession | NM_033343 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2F3 |
| Calculated MW | 43124 Da |
| Gene ID | 89884 |
|---|---|
| Other Names | LIM/homeobox protein Lhx4, LIM homeobox protein 4, LHX4 |
| Target/Specificity | LHX4 (NP_203129, 208 a.a. ~ 306 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | LHX4 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined.
REFERENCES
Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion. Dateki S, et al. J Clin Endocrinol Metab, 2010 Aug. PMID 20534763.A novel dysfunctional LHX4 mutation with high phenotypical variability in patients with hypopituitarism. Castinetti F, et al. J Clin Endocrinol Metab, 2008 Jul. PMID 18445675.Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies. Pfaeffle RW, et al. J Clin Endocrinol Metab, 2008 Mar. PMID 18073311.Specificity protein 1 (Sp1) plays role in regulating LIM homeodomain transcription factor Lhx4 gene expression. Liu S, et al. Biochem Biophys Res Commun, 2008 Feb 1. PMID 18053794.The C terminus of the synovial sarcoma-associated SSX proteins interacts with the LIM homeobox protein LHX4. de Bruijn DR, et al. Oncogene, 2008 Jan 24. PMID 17667940.
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