LETM1 Antibody (monoclonal) (M03)

Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.

REFERENCES

1.High Expression of Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 Predicts Poor Prognosis in Head and Neck Squamous Cell Carcinoma.Chen L, Yang Y, Liu S, Piao L, Zhang Y, Lin Z, Li Z.BioMed Research International Volume 2014, Article ID 850316,8 pages2.Co-delivery of LETM1 and CTMP synergistically inhibits tumor growth in H-ras12V liver cancer model mice.Shin JY, Chung YS, Kang B, Jiang HL, Yu DY, Han K, Chae C, Moon JH, Jang G, Cho MHCancer Gene Ther. 2013 Feb 8. doi: 10.1038/cgt.2013.6.3.Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death.Piao L, Li Y, Kim SJ, Byun HS, Huang SM, Hwang SK, Yang KJ, Park KA, Won M, Hong J, Hur GM, Seok JH, Shong M, Cho MH, Brazil DP, Hemmings BA, Park J.Cancer Res. 2009 Apr 15;69(8):3397-404. Epub 2009 Mar 24.4.Regulation of OPA1-mediated mitochondrial fusion by Leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis.Piao L, Li Y, Kim SJ, Sohn KC, Yang KJ, Park KA, Byun HS, Won M, Hong J, Hur GM, Seok JH, Shong M, Sack R, Brazil DP, Hemmings BA, Park J.Cell Signal. 2009 May;21(5):767-77. Epub 2009 Jan 9.5.LETM1, deleted in Wolf Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability.Dimmer KS, Navoni F, Casarin A, Trevisson E, Endele S, Winterpacht A, Salviati L, Scorrano L.Hum Mol Genet. 2008 Jan 15;17(2):201-14. Epub 2007 Oct 9.