癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KCNJ15 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant KCNJ15.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q99712 |
| Other Accession | NM_002243 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1B2 |
| Calculated MW | 42577 Da |
| Gene ID | 3772 |
|---|---|
| Other Names | ATP-sensitive inward rectifier potassium channel 15, Inward rectifier K(+) channel Kir13, Inward rectifier K(+) channel Kir42, Potassium channel, inwardly rectifying subfamily J member 15, KCNJ15, KCNJ14 |
| Target/Specificity | KCNJ15 (NP_002234, 290 a.a. ~ 355 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KCNJ15 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Three transcript variants encoding the same protein have been found for this gene.
REFERENCES
Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. Okamoto K, et al. Am J Hum Genet, 2010 Jan. PMID 20085713.MUPP1 complexes renal K+ channels to alter cell surface expression and whole cell currents. Sindic A, et al. Am J Physiol Renal Physiol, 2009 Jul. PMID 19420109.Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Ji W, et al. Nat Genet, 2008 May. PMID 18391953.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function. Huang C, et al. Am J Physiol Renal Physiol, 2007 Mar. PMID 17122384.
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