癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IL10 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant IL10.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P22301 |
| Other Accession | NM_000572 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG3 Kappa |
| Clone Names | 1C10 |
| Calculated MW | 20517 Da |
| Gene ID | 3586 |
|---|---|
| Other Names | Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, IL10 |
| Target/Specificity | IL10 (AAI04253.1, 74 a.a. ~ 178 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | IL10 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
REFERENCES
Association of Interleukin-10 Polymorphisms with Cytokines in Type 2 Diabetic Nephropathy. Kung WJ, et al. Diabetes Technol Ther, 2010 Sep 1. PMID 20809684.Interleukin-10 microsatellite variants and the risk of acute coronary syndrome among Tunisians. Ben-Hadj-Khalifa-Kechiche S, et al. Int J Immunogenet, 2010 Aug 29. PMID 20807264.Intereleukin-10 promoter polymorphism in mild cognitive impairment and in its clinical evolution. Arosio B, et al. Int J Alzheimers Dis, 2010 Jul 20. PMID 20798845.The associations between two polymorphisms in the interleukin-10 gene promoter and breast cancer risk. Yu KD, et al. Breast Cancer Res Treat, 2010 Aug 25. PMID 20737205.Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese. Liu J, et al. BMC Cancer, 2010 Aug 24. PMID 20735825.
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