癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HEPH Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant HEPH.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BQS7 |
| Other Accession | NM_138737 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2D3 |
| Calculated MW | 130449 Da |
| Gene ID | 9843 |
|---|---|
| Other Names | Hephaestin, 1---, HEPH, KIAA0698 |
| Target/Specificity | HEPH (NP_620074, 315 a.a. ~ 424 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HEPH Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is similar to an iron transport protein found in mouse. The mouse protein is similar to ceruloplasmin, a serum multi-copper ferroxidase, and is thought to be a membrane-bound protein responsible for transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system. In mouse, defects in this gene can lead to severe microcytic anemia. Three transcript variants encoding different isoforms have been described for this gene.
REFERENCES
Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. Ucisik-Akkaya E, et al. Mol Hum Reprod, 2010 Oct. PMID 20587610.Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic {beta}-cells. Hudson DM, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Mar. PMID 20019163.Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells. Chen H, et al. J Cell Biochem, 2009 Jul 1. PMID 19452451.Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin. Hudson DM, et al. J Cell Biochem, 2008 Apr 15. PMID 18022819.Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells. Han O, et al. J Cell Biochem, 2007 Jul 1. PMID 17486601.
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