癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FZD2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant FZD2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q14332 |
| Other Accession | NM_001466 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2C8 |
| Calculated MW | 63554 Da |
| Gene ID | 2535 |
|---|---|
| Other Names | Frizzled-2, Fz-2, hFz2, FzE2, FZD2 |
| Target/Specificity | FZD2 (NP_001457, 192 a.a. ~ 245 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FZD2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.
REFERENCES
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. Bazhin AV, et al. Cell Mol Life Sci, 2010 Mar. PMID 19946729.Wnt5a regulates distinct signalling pathways by binding to Frizzled2. Sato A, et al. EMBO J, 2010 Jan 6. PMID 19910923.Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. Ollila HM, et al. Mol Psychiatry, 2009 Apr. PMID 19308021.Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Wang HX, et al. Mol Hum Reprod, 2009 Jan. PMID 19038973.
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