癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FIS1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant FIS1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q9Y3D6 |
| Other Accession | BC003540 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 1G9 |
| Calculated MW | 16938 Da |
| Gene ID | 51024 |
|---|---|
| Other Names | Mitochondrial fission 1 protein, FIS1 homolog, hFis1, Tetratricopeptide repeat protein 11, TPR repeat protein 11, FIS1, TTC11 |
| Target/Specificity | FIS1 (AAH03540.1, 1 a.a. ~ 152 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FIS1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).
REFERENCES
Specific mitochondrial calcium overload induces mitochondrial fission in prostate cancer cells. Kaddour-Djebbar I, et al. Int J Oncol, 2010 Jun. PMID 20428767. Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. Mai S, et al. J Cell Sci, 2010 Mar 15. PMID 20179104. Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1. Serasinghe MN, et al. J Biol Chem, 2010 Jan 1. PMID 19864424. The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction. Serasinghe MN, et al. Exp Cell Res, 2008 Nov 15. PMID 18845145. Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. Park KS, et al. J Biol Chem, 2008 Nov 28. PMID 18832378.
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