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>   首页   >   产品   >   一抗   >   癌症   >   FASN Antibody (monoclonal) (M01)   

FASN Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant FASN.

     
  • 1 - FASN Antibody (monoclonal) (M01) AT2002a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (74.03 KDa) .
  • 1 - FASN Antibody (monoclonal) (M01) AT2002a
    FASN monoclonal antibody (M01), clone 3F2-1F3 Western Blot analysis of FASN expression in 293 ( (Cat # AT2002a )
  • 1 - FASN Antibody (monoclonal) (M01) AT2002a
    Western Blot analysis of FASN expression in transfected 293T cell line by FASN monoclonal antibody (M01), clone 3F2-1F3.

    Lane 1: FASN transfected lysate(48.3 KDa).
    Lane 2: Non-transfected lysate.
  • 2 - FASN Antibody (monoclonal) (M01) AT2002a
    Immunoperoxidase of monoclonal antibody to FASN on formalin-fixed paraffin-embedded human breast cancer tissue. [antibody concentration 10 ug/ml]
  • 3 - FASN Antibody (monoclonal) (M01) AT2002a
    Immunofluorescence of monoclonal antibody to FASN on HeLa cell. [antibody concentration 10 ug/ml]
  • 5 - FASN Antibody (monoclonal) (M01) AT2002a
    Immunoprecipitation of FASN transfected lysate using anti-FASN monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with FASN MaxPab rabbit polyclonal antibody.
    U0007), and immunoblotted with FASN MaxPab rabbit polyclonal antibody." href="/assets/uploads/products/200811/AT2002a_image_6.jpg">
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IF, IP
Primary Accession P49327
Other Accession BC007909
Reactivity Human
Host Mouse
Clonality monoclonal
Isotype IgG1 kappa
Clone Names 3F2-1F3
Calculated MW 273427 Da
Additional Information
Gene ID 2194
Other Names Fatty acid synthase, [Acyl-carrier-protein] S-acetyltransferase, [Acyl-carrier-protein] S-malonyltransferase, 3-oxoacyl-[acyl-carrier-protein] synthase, 3-oxoacyl-[acyl-carrier-protein] reductase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, Enoyl-[acyl-carrier-protein] reductase, Oleoyl-[acyl-carrier-protein] hydrolase, FASN, FAS
Target/Specificity FASN (AAH07909, 1 a.a. ~ 439 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
IHC~~1:100~500
IF~~1:50~200
IP~~N/A
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsFASN Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

REFERENCES

1.Old proteins - new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells.Gorr TA, Wichmann D, Pilarsky C, Theurillat JP, Fabrizius A, Laufs T, Bauer T, Koslowski M, Horn S, Burmester T, Hankeln T, Kristiansen G.Acta Physiol (Oxf). 2011 Jul;202(3):563-581.2.Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype.Kristiansen G, Rose M, Geisler C, Fritzsche FR, Gerhardt J, Luke C, Ladhoff AM, Knuchel R, Dietel M, Moch H, Varga Z, Theurillat JP, Gorr TA, Dahl E.Br J Cancer. 2010 Jun 8;102(12):1736-45.

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