癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FANCG Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant FANCG.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, IP, E |
|---|---|
| Primary Accession | O15287 |
| Other Accession | BC011623 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 2C8 |
| Calculated MW | 68554 Da |
| Gene ID | 2189 |
|---|---|
| Other Names | Fanconi anemia group G protein, Protein FACG, DNA repair protein XRCC9, FANCG, XRCC9 |
| Target/Specificity | FANCG (AAH11623, 1 a.a. ~ 622 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FANCG Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G.
REFERENCES
1.Areca Nut Induces miR-23a and Inhibits Repair of DNA Double-Strand Breaks by Targeting FANCG.Tsai YS, Lin CS, Chiang SL, Lee CH, Lee KW, Ko YC.Toxicol Sci. 2011 Oct;123(2):480-90. Epub 2011 Jul 12.2.Stimulation of Homology-directed Repair at I-SceI-induced DNA breaks during the Permissive Life Cycle of Human Cytomegalovirus.Kulkarni AS, Fortunato EA.J Virol. 2011 Apr 13. [Epub ahead of print]3.Four human FANCG polymorphic variants show normal biological function in hamster CHO cells.Hinz JM, Nham PB, Yamada NA, Tebbs RS, Salazar EP, Hinz AK, Mohrenweiser HW, Jones IM, Thompson LH.Mutat Res. 2006 Dec 1;602(1-2):34-42. Epub 2006 Sep 28.
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