癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EPHA2 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant EPHA2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF |
|---|---|
| Primary Accession | P29317 |
| Other Accession | BC037166 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG3 Kappa |
| Clone Names | 1E4 |
| Calculated MW | 108266 Da |
| Gene ID | 1969 |
|---|---|
| Other Names | Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, EPHA2, ECK |
| Target/Specificity | EPHA2 (AAH37166, 204 a.a. ~ 326 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | EPHA2 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
REFERENCES
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. Hiramoto-Yamaki N, et al. J Cell Biol, 2010 Aug 9. PMID 20679435.EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Lee JW, et al. Clin Cancer Res, 2010 May 1. PMID 20388851.Autosomal recessive congenital cataract linked to EPHA2 in a consanguineous Pakistani family. Kaul H, et al. Mol Vis, 2010 Mar 24. PMID 20361013.EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation. Faoro L, et al. J Biol Chem, 2010 Jun 11. PMID 20360610.An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly. Seiradake E, et al. Nat Struct Mol Biol, 2010 Apr. PMID 20228801.
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