癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DKK1 Antibody (monoclonal) (M11)
Mouse monoclonal antibody raised against a full length recombinant DKK1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IP |
|---|---|
| Primary Accession | O94907 |
| Other Accession | BC001539 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2A5 |
| Calculated MW | 28672 Da |
| Gene ID | 22943 |
|---|---|
| Other Names | Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1 |
| Target/Specificity | DKK1 (AAH01539.1, 1 a.a. ~ 266 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IP~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DKK1 Antibody (monoclonal) (M11) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
REFERENCES
1.Genetic grouping of medulloblastomas by representative markers in pathologic diagnosis.Min HS, Lee JY, Kim SK, Park SHTransl Oncol. 2013 Jun 1;6(3):265-72. Print 2013 Jun.2.RNA interference?mediated targeting of DKK1 gene expression in Ishikawa endometrial carcinoma cells causes increased tumor cell invasion and migration.Yi N, Liao QP, Li ZH, Xie BJ, Hu YH, Yi W, Liu M.ONCOLOGY LETTERS 6: 756-762, 20133.Molecular subgroups of medulloblastoma: the current consensus.Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM.Acta Neuropathol. 2011 Dec 2.4.Prokineticin 1 induces Dickkopf 1 expression and regulates cell proliferation and decidualization in the human endometrium.Macdonald LJ, Sales KJ, Grant V, Brown P, Jabbour HN, Catalano RD.Mol Hum Reprod. 2011 May 5. [Epub ahead of print]5.Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion.Shin HJ, Rho SB, Jung DC, Han IO, Oh ES, Kim JY.J Cell Sci. 2011 Apr 1;124(Pt 7):1077-87. Epub 2011 Mar 1.6.Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures.D'Amelio P, Roato I, D'Amico L, Veneziano L, Suman E, Sassi F, Bisignano G, Ferracini R, Gargiulo G, Castoldi F, Pescarmona GP, Isaia GC.Osteoporos Int. 2010 Nov 30. [Epub ahead of print]
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