癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DFNB31 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant DFNB31.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9P202 |
| Other Accession | NM_015404 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 1D9 |
| Calculated MW | 96558 Da |
| Gene ID | 25861 |
|---|---|
| Other Names | Whirlin, Autosomal recessive deafness type 31 protein, DFNB31, KIAA1526, WHRN |
| Target/Specificity | DFNB31 (NP_056219, 808 a.a. ~ 907 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DFNB31 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is thought to function in the organization and stabilization of sterocilia elongation and actin cystoskeletal assembly, based on studies of the related mouse gene. Mutations in this gene have been associated with autosomal recessive non-syndromic deafness and Usher Syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
REFERENCES
Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. Letra A, et al. Am J Med Genet A, 2010 Jul. PMID 20583170.Family-based association study for bipolar affective disorder. Secolin R, et al. Psychiatr Genet, 2010 Jun. PMID 20414141.Sequence variants of the DFNB31 gene among Usher syndrome patients of diverse origin. Aller E, et al. Mol Vis, 2010 Mar 23. PMID 20352026.Overexpression of the signal peptide whirlin isoform 2 is related to disease progression in colorectal cancer patients. Toiyama Y, et al. Int J Oncol, 2009 Oct. PMID 19724906.Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. Ollila HM, et al. Mol Psychiatry, 2009 Apr. PMID 19308021.
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