癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DEFB4 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant DEFB4.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O15263 |
| Other Accession | NM_004942 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4C4 |
| Calculated MW | 7038 Da |
| Gene ID | 100289462;1673 |
|---|---|
| Other Names | Beta-defensin 4A, Beta-defensin 2, BD-2, hBD-2, Defensin, beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB4A, DEFB102, DEFB2, DEFB4 |
| Target/Specificity | DEFB4 (NP_004933, 24 a.a. ~ 64 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DEFB4 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation.
REFERENCES
Polymorphisms of Beta Defensins Are Associated with the Risk of Severe Acute Pancreatitis. Tiszlavicz Z, et al. Pancreatology, 2010 Aug 19. PMID 20720450.Differential and coordinated expression of defensins and cytokines by gingival epithelial cells and dendritic cells in response to oral bacteria. Yin L, et al. BMC Immunol, 2010 Jul 9. PMID 20618959.Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. R?hrl J, et al. J Immunol, 2010 Jun 15. PMID 20483750.Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease. Janssens W, et al. Am J Respir Crit Care Med, 2010 Jul 15. PMID 20378733.Bacteroides fragilis enterotoxin induces human beta-defensin-2 expression in intestinal epithelial cells via a mitogen-activated protein kinase/I kappaB kinase/NF-kappaB-dependent pathway. Yoon YM, et al. Infect Immun, 2010 May. PMID 20231411.
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