癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CMTM5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CKLFSF5.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96DZ9 |
| Other Accession | BC013109 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 2G1-6B10 |
| Calculated MW | 24653 Da |
| Gene ID | 116173 |
|---|---|
| Other Names | CKLF-like MARVEL transmembrane domain-containing protein 5, Chemokine-like factor superfamily member 5, CMTM5, CKLFSF5 |
| Target/Specificity | CKLFSF5 (AAH13109, 1 a.a. ~ 156 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CMTM5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene belongs to the chemokine-like factor gene superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
REFERENCES
CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway. Li H, et al. BMB Rep, 2010 Mar. PMID 20356458.CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha. Guo X, et al. Biochem Biophys Res Commun, 2009 Sep 11. PMID 19577543.CMTM5-v1 induces apoptosis in cervical carcinoma cells. Shao L, et al. Biochem Biophys Res Commun, 2009 Feb 20. PMID 19124004.CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines. Shao L, et al. Clin Cancer Res, 2007 Oct 1. PMID 17908965.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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