癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CAPG Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CAPG.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P40121 |
| Other Accession | BC000728 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1F1 |
| Calculated MW | 38499 Da |
| Gene ID | 822 |
|---|---|
| Other Names | Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP |
| Target/Specificity | CAPG (AAH00728.1, 1 a.a. ~ 348 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CAPG Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described.
REFERENCES
Proteomic study of macrophages exposed to oxLDL identifies a CAPG polymorphism associated with carotid atherosclerosis. Burillo E, et al. Atherosclerosis, 2009 Nov. PMID 19439302.Proteomic analysis of the stroma-related proteins in nasopharyngeal carcinoma and normal nasopharyngeal epithelial tissues. Li MX, et al. Med Oncol, 2010 Mar. PMID 19242827.Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia. Zhang R, et al. Am J Respir Cell Mol Biol, 2009 Oct. PMID 19188659.The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle. Hubert T, et al. Biochem Biophys Res Commun, 2009 Feb 27. PMID 19166812.Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. Chen M, et al. J Biol Chem, 2009 Jan 16. PMID 19011242.
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