癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ASAHL Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant NAAA.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q02083 |
| Other Accession | NM_014435 |
| Reactivity | Human, Mouse |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5E4 |
| Calculated MW | 40066 Da |
| Gene ID | 27163 |
|---|---|
| Other Names | N-acylethanolamine-hydrolyzing acid amidase, 351-, Acid ceramidase-like protein, N-acylsphingosine amidohydrolase-like, ASAH-like protein, N-acylethanolamine-hydrolyzing acid amidase subunit alpha, N-acylethanolamine-hydrolyzing acid amidase subunit beta, NAAA, ASAHL, PLT |
| Target/Specificity | NAAA (NP_055250, 36 a.a. ~ 104 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ASAHL Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. M?ller TD, et al. Child Adolesc Psychiatry Ment Health, 2008 Nov 17. PMID 19014633.Expression and secretion of N-acylethanolamine-hydrolysing acid amidase in human prostate cancer cells. Wang J, et al. J Biochem, 2008 Nov. PMID 18806270.Overexpression and mass spectrometry analysis of mature human acid ceramidase. Schulze H, et al. Biol Chem, 2007 Dec. PMID 18020949.Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism. Zhao LY, et al. Biochim Biophys Acta, 2007 Nov. PMID 17980170.Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674.
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