癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
APLN Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant APLN.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9ULZ1 |
| Other Accession | BC021104.1 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1A8-2A5 |
| Calculated MW | 8569 Da |
| Gene ID | 8862 |
|---|---|
| Other Names | Apelin, APJ endogenous ligand, Apelin-36, Apelin-31, Apelin-28, Apelin-13, APLN, APEL |
| Target/Specificity | APLN (AAH21104.1, 1 a.a. ~ 122 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | APLN Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
REFERENCES
Elevated plasma levels of apelin in children with type 1 diabetes mellitus. Meral C, et al. J Pediatr Endocrinol Metab, 2010 May. PMID 20662349.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Plasma apelin and ADMA Levels in patients with essential hypertension. Sonmez A, et al. Clin Exp Hypertens, 2010 May. PMID 20504125.Validation of genetic association in apelin-AGTRL1 system with hypertension in a larger Han Chinese population. Niu W, et al. J Hypertens, 2010 Sep. PMID 20485192.Assessment of serum apelin levels in girls with anorexia nervosa. Ziora K, et al. J Clin Endocrinol Metab, 2010 Jun. PMID 20382684.
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