癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ADA Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant ADA.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P00813 |
| Other Accession | BC040226 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4G4-1C6 |
| Calculated MW | 40764 Da |
| Gene ID | 100 |
|---|---|
| Other Names | Adenosine deaminase, Adenosine aminohydrolase, ADA, ADA1 |
| Target/Specificity | ADA (AAH40226.1, 1 a.a. ~ 363 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ADA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia.
REFERENCES
An indication for correlation between the serum ADA level and gastric cancer risk. Ri G, et al. Anticancer Res, 2010 Jun. PMID 20651391.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. Levine AJ, et al. Cancer Epidemiol Biomarkers Prev, 2010 Jul. PMID 20615890.A Study of Three Polymorphic Sites of ADA Gene in Colon Cancer. Spina C, et al. Cancer Invest, 2010 Jun 30. PMID 20590444.The interaction of ACP1, ADA1, diabetes and gender in coronary artery disease. Gloria-Bottini F, et al. Am J Med Sci, 2010 Aug. PMID 20581655.
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