癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ABCC6 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant ABCC6.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O95255 |
| Other Accession | NM_001171 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 1E7 |
| Calculated MW | 164906 Da |
| Gene ID | 368 |
|---|---|
| Other Names | Multidrug resistance-associated protein 6, ATP-binding cassette sub-family C member 6, Anthracycline resistance-associated protein, Multi-specific organic anion transporter E, MOAT-E, ABCC6, ARA, MRP6 |
| Target/Specificity | ABCC6 (NP_001162, 831 a.a. ~ 930 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ABCC6 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.
REFERENCES
Analysis of MMP2 promoter polymorphisms in patients with pseudoxanthoma elasticum. Zarbock R, et al. Clin Chim Acta, 2010 Oct 9. PMID 20541540.The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes. de Boussac H, et al. J Biol Chem, 2010 Jul 23. PMID 20463007.Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region. Costrop LM, et al. J Hum Genet, 2010 Feb. PMID 20075945.Pseudoxanthoma elasticum: molecular genetics and putative pathomechanisms. Uitto J, et al. J Invest Dermatol, 2010 Mar. PMID 20032990.The R1141X loss-of-function mutation of the ABCC6 gene is a strong genetic risk factor for coronary artery disease. K?bl?s G, et al. Genet Test Mol Biomarkers, 2010 Feb. PMID 19929409.
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