癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC30A8 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IWU4 |
| Other Accession | 64762489, NP_776250, 169026 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 40755 Da |
| Application Notes | SLC30A8 antibody can be used for Western blot at 1 - 2 µg/mL. |
| Gene ID | 169026 |
|---|---|
| Other Names | SLC30A8 Antibody: Solute carrier family 30 member 8, zinc transporter 8, ZNT8, Zn-T8 |
| Precautions | SLC30A8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC30A8 (HGNC:20303) |
|---|---|
| Function | Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Associated with insulin and glucagon secretory granules. |
| Tissue Location | In the endocrine pancreas, expressed in insulin- producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SLC30A8 Antibody: SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells (1). Allelic variants of SLC30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes (2), but no genetic association has been found with Type 1 diabetes (3). SLC30A8 expression in β-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4).
REFERENCES
Chimienti F, Devergnas S, Favier A, et al. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004; 53:2330-7.;Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study indentifies novel risk loci for type 2 diabetes. Science 2007; 445:881-5.;Qu HQ, Grant SF, Bradfield JP, et al. Association analysis of type 2 diabetes Loci in type 1 diabetes. Diabetes 2008; 57:1983-6.;Egefjord L, Jensen JL, Bang-Berthelsen CH, et al. Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis? BMC Endocrine Disorders 2009; 9:7.
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