癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MYH8 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | P13535 |
| Other Accession | NP_002463, 153945790 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 222763 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | MYH8 antibody can be used for detection of MYH8 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 4626 |
|---|---|
| Other Names | Myosin-8, Myosin heavy chain 8, Myosin heavy chain, skeletal muscle, perinatal, MyHC-perinatal, MYH8 |
| Target/Specificity | MYH8; MYH8 antibody is human, mouse and rat reactive. MYH8 antibody is predicted to not cross-react with other members of the myosin heavy chain family. |
| Reconstitution & Storage | MYH8 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | MYH8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYH8 |
|---|---|
| Function | Muscle contraction. |
| Cellular Location | Cytoplasm, myofibril. Note=Thick filaments of the myofibrils |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells (1). MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal) is a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction (2,3). This gene is predominantly expressed in fetal skeletal muscle. MYH8 is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations (3). A mutation in this gene results in trismus-pseudocamptodactyly syndrome (4).
REFERENCES
Yu H, Waddell JN, Kuang S, et al. Park7 expression influences myotube size and myosin expression in muscle. PLoS One 2014; 9:e92030.
Feghali R and Leinwand LA. Molecular genetic characterization of a developmentally regulated human perinatal myosin heavy chain. J. Cell Biol. 1989; 108:1791-7.
Jullian EH, Kelly AM, Pompidou AJ, et al. Characterization of a human perinatal myosin heavy-chain transcript. Eur. J. Biochem. 1995; 230:1001-6.
Minzer-Conzetti K, Wu E, Vargervik K, et al. Phenotypic variation in trismus-pseudocamptodactyly syndrome caused by a recurrent MYH8 mutation. Clin. Dysmorphol. 2008; 17:1-4.
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