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>   首页   >   产品   >   一抗   >   基因重组   >   Anti-FZD7 Reference Antibody (U.Toronto patent anti-FZD7)   

Anti-FZD7 Reference Antibody (U.Toronto patent anti-FZD7)

Recombinant Antibody

     
  • 1 - Anti-FZD7 Reference Antibody (U.Toronto patent anti-FZD7) APR10914
    Anti-FZD7 Reference Antibody (U.Toronto patent anti-FZD7) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%
  • 1 - Anti-FZD7 Reference Antibody (U.Toronto patent anti-FZD7) APR10914
    The purity of Anti-FZD7 Reference Antibody (U.Toronto patent anti-FZD7)is more than 95% ,determined by SEC-HPLC.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, Kinetics, Animal Model
Primary Accession O75084
Reactivity Human
Clonality Monoclonal
Isotype IgG1
Calculated MW 63620 Da
Additional Information
Target/Specificity FZD7
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name FZD7
Function Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Cellular Location Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions
Tissue Location High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta Specifically expressed in squamous cell esophageal carcinomas
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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