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>   首页   >   产品   >   一抗   >   基因重组   >   Anti-CLEC7A Reference Antibody (Baylor patent anti-Dectin-1)   

Anti-CLEC7A Reference Antibody (Baylor patent anti-Dectin-1)

Recombinant Antibody

     
  • 1 - Anti-CLEC7A Reference Antibody (Baylor patent anti-Dectin-1) APR10838
    Anti-CLEC7A Reference Antibody (Baylor patent anti-Dectin-1) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%
  • 1 - Anti-CLEC7A Reference Antibody (Baylor patent anti-Dectin-1) APR10838
    The purity of Anti-CLEC7A Reference Antibody (Baylor patent anti-Dectin-1)is more than 95% ,determined by SEC-HPLC.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, Kinetics, Animal Model
Primary Accession Q9BXN2
Reactivity Human
Clonality Monoclonal
Isotype IgG4
Calculated MW 27627 Da
Additional Information
Target/Specificity CLEC7A
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name CLEC7A (HGNC:14558)
Function Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed:17230442). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).
Cellular Location Cell membrane; Single-pass type II membrane protein [Isoform 6]: Cytoplasm.
Tissue Location Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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