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>   首页   >   产品   >   一抗   >   基因重组   >   Anti-ASIC1 Reference Antibody (Regeneron patent anti-ASIC1)   

Anti-ASIC1 Reference Antibody (Regeneron patent anti-ASIC1)

Recombinant Antibody

     
  • 1 - Anti-ASIC1 Reference Antibody (Regeneron patent anti-ASIC1) APR10786
    Anti-ASIC1 Reference Antibody (Regeneron patent anti-ASIC1) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
  • 1 - Anti-ASIC1 Reference Antibody (Regeneron patent anti-ASIC1) APR10786
    The purity of Anti-ASIC1 Reference Antibody (Regeneron patent anti-ASIC1)is more than 95% ,determined by SEC-HPLC.
  • 产品详情
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, Kinetics, Animal Model
Primary Accession P78348
Reactivity Human
Clonality Monoclonal
Isotype IgG1
Calculated MW 59909 Da
Additional Information
Target/Specificity ASIC1
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name ASIC1 (HGNC:100)
Function Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:21036899, PubMed:32915133, PubMed:34319232). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:21036899). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:21036899). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q6NXK8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q6NXK8}. Note=Isolated in synaptosomes from the dendritic synapses of neurons {ECO:0000250|UniProtKB:Q6NXK8}
Tissue Location Expressed in neurons throughout the central and peripheral nervous system.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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