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>   首页   >   产品   >   一抗   >   基因重组   >   Anti-FcRn (FCGRT & B2M) Reference Antibody (orilanolimab)   

Anti-FcRn (FCGRT & B2M) Reference Antibody (orilanolimab)

Recombinant Antibody

     
  • 1 - Anti-FcRn (FCGRT & B2M) Reference Antibody (orilanolimab) APR10263
    Anti-FcRn (FCGRT & B2M) Reference Antibody (orilanolimab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
  • 1 - Anti-FcRn (FCGRT & B2M) Reference Antibody (orilanolimab) APR10263
    The purity of Anti-FcRn (FCGRT & B2M) Reference Antibody (orilanolimab)is more than 92.74% ,determined by SEC-HPLC.
  • 1 - Anti-FcRn (FCGRT & B2M) Reference Antibody (orilanolimab) APR10263
    Immobilized FcRn(FCGRT) His+FcRn(B2M) at 2  µg/mL can bind Anti-FcRn (FCGRT & B2M) Reference Antibody (orilanolimab),EC50=0.0311 µg/mL
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, Kinetics, Animal Model
Primary Accession P55899
Reactivity Human
Clonality Monoclonal
Isotype IgG1
Calculated MW 39743 Da
Additional Information
Target/Specificity FcRn (FCGRT & B2M)
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name FCGRT
Synonyms FCRN
Function Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:10933786, PubMed:7964511). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane protein. Endosome membrane
Tissue Location Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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