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>   首页   >   产品   >   一抗   >   基因重组   >   Anti-Complement Factor D Reference Antibody (lampalizumab)   

Anti-Complement Factor D Reference Antibody (lampalizumab)

Recombinant Antibody

     
  • 1 - Anti-Complement Factor D Reference Antibody (lampalizumab) APR10146
    Anti-Complement Factor D Reference Antibody (lampalizumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
  • 1 - Anti-Complement Factor D Reference Antibody (lampalizumab) APR10146
    The purity of Anti-Complement Factor D Reference Antibody (lampalizumab)is more than 99.38% ,determined by SEC-HPLC.
  • 1 - Anti-Complement Factor D Reference Antibody (lampalizumab) APR10146
    Immobilized human Complement Factor D,  Fc at 2  µg/mL can bind Anti-Complement Factor D Reference Antibody (lampalizumab),EC50=0.02371 µg/mL
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, Kinetics, Animal Model
Primary Accession P00746
Reactivity Human, Rabbit
Clonality Monoclonal
Isotype IgG1
Calculated MW 27033 Da
Additional Information
Target/Specificity Complement Factor D
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name CFD (HGNC:2771)
Synonyms DF, PFD
Function Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:21205667, PubMed:22362762, PubMed:6769474, PubMed:874324, PubMed:9748277). In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3 (PubMed:21205667, PubMed:22362762, PubMed:6769474, PubMed:874324). The alternative complement pathway acts as an amplification loop that enhances complement activation by mediating the formation of C3 and C5 convertases (PubMed:21205667, PubMed:22362762, PubMed:6769474, PubMed:874324). Activated CFD cleaves factor B (CFB) when the latter is complexed with complement C3b, activating the C3 convertase of the alternative pathway (PubMed:21205667, PubMed:6769474, PubMed:874324, PubMed:9748277).
Cellular Location Secreted
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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