PR3 Mouse mAb
PR3 Mouse mAb
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| IHC-P, IHC-F, IF, ICC |
---|---|
Host | Rabbit |
Clonality | Monoclonal |
Calculated MW | 28 KDa |
Physical State | Lyophilized or Liquid |
Immunogen | Recombinant human PR3 |
Isotype | IgG |
Purity | affinity purified by Protein A |
Buffer | 0.01M PBS(pH7.4) |
SIMILARITY | Belongs to the peptidase S1 family. Elastase subfamily. Contains 1 peptidase S1 domain. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Background Descriptions | The major features of Wegener granulomatosis are necrotizing granulomatous lesions, which most often affect the upper and lower airways and are associated with vasculitis, necrotizing glomerulonephritis and pulmonary capillaritis. The antigen responsible for this disease is Proteinase 3 (PR3, P29 or myeloblastin), which is one of the antibiotic proteins of neutrophilic granules belonging to the serine protease family. It is closely related to two others: Neutrophil Elastase and azurocidin. All three genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. PR3 is a neutrophil protein which is able to cleave elastin and is involved in proliferation of human leukemia cells. PR3 is expressed specifically in immature myeloid cells and is a G-CSF-responsive protein critical to factor-independent growth. The genes for all three of the related serine protease family members are located in a cluster on the tip of the short arm of human chromosome 19. |
Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100 |
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Format | 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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