癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AFM Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P43652 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 69069 Da |
| Antigen Region | 49-76 aa |
| Gene ID | 173 |
|---|---|
| Other Names | Afamin, Alpha-albumin, Alpha-Alb, AFM, ALB2, ALBA |
| Target/Specificity | This AFM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-76 amino acids from the N-terminal region of human AFM. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AFM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AFM |
|---|---|
| Synonyms | ALB2, ALBA |
| Function | Functions as a carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B (PubMed:26902720). Binds vitamin E (PubMed:12463752, PubMed:15952736). May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient (PubMed:15952736). May be involved in the transport of vitamin E across the blood-brain barrier (PubMed:19046407). |
| Cellular Location | Secreted |
| Tissue Location | High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
AFM is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.
REFERENCES
Dieplinger, H., et al. Cancer Epidemiol. Biomarkers Prev. 18(4):1127-1133(2009)
Kratzer, I., et al. J. Neurochem. 108(3):707-718(2009)
Ramachandran, P., et al. J. Proteome Res. 5(6):1493-1503(2006)
Hu, Y., et al. Mol. Cell Proteomics 4(12):2000-2009(2005)
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
Bunkenborg, J., et al. Proteomics 4(2):454-465(2004)
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