癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PLIN5 (10J6) Mouse Monoclonal antibody
PLIN5 (10J6) Mouse Monoclonal antibody
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Application 
| WB, IHC |
|---|---|
| Primary Accession | Q00G26 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Calculated MW | 50791 Da |
| Gene ID | 440503 |
|---|---|
| Other Names | Perilipin-5, Lipid storage droplet protein 5, PLIN5, LSDP5, OXPAT, PAT-1 |
| Dilution | WB~~1:1000 IHC~~1:100~500 |
| Storage Conditions | -20℃ |
| Name | PLIN5 |
|---|---|
| Synonyms | LSDP5, OXPAT, PAT-1 |
| Function | Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). |
| Cellular Location | Lipid droplet. Cytoplasm {ECO:0000250|UniProtKB:Q8BVZ1}. Mitochondrion {ECO:0000250|UniProtKB:M0R7Z9}. Note=Lipid droplet surface-associated Exchanges between lipid droplets and the cytoplasm {ECO:0000250|UniProtKB:Q8BVZ1} |
| Tissue Location | Expressed in skeletal muscle, liver, heart and kidney. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Members of the perilipin family, such as PLIN5, coat intracellular lipid storage droplets and protect them from lipolytic degradation (Dalen et al., 2007 [PubMed 17234449]). [supplied by OMIM, Feb 2010]
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