癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ALK-1 (9M14) Rabbit Monoclonal Antibody
ALK-1 (9M14) Rabbit Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P80203 |
| Reactivity | Rat, Mouse |
| Clonality | Monoclonal |
| Calculated MW | 56703 Da |
| Gene ID | 25237 |
|---|---|
| Other Names | Activin receptor type-1-like, 2.7.11.30, Serine/threonine-protein kinase receptor R3, SKR3, TGF-B superfamily receptor type I, TSR-I, Acvrl1, Acvrlk1 |
| Dilution | WB~~1:1000 |
| Storage Conditions | -20℃ |
| Name | Acvrl1 |
|---|---|
| Synonyms | Acvrlk1 |
| Function | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P37023}; Single-pass type I membrane protein |
| Tissue Location | Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development
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