IGFBP5 (18K8) Rabbit Monoclonal Antibody
IGFBP5 (18K8) Rabbit Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IP |
---|---|
Primary Accession | P24594 |
Reactivity | Rat, Mouse |
Clonality | Monoclonal |
Calculated MW | 30298 Da |
Gene ID | 25285 |
---|---|
Other Names | Insulin-like growth factor-binding protein 5, IBP-5, IGF-binding protein 5, IGFBP-5, Igfbp5, Igfbp-5 |
Dilution | WB~~1:1000 IP~~N/A |
Storage Conditions | -20℃ |
Name | Igfbp5 |
---|---|
Synonyms | Igfbp-5 |
Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:23417767). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells (By similarity). Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (By similarity). |
Cellular Location | Secreted {ECO:0000250|UniProtKB:P24593}. Cytoplasm {ECO:0000250|UniProtKB:P24593}. Nucleus {ECO:0000250|UniProtKB:P24593} |
Tissue Location | Mostly in kidney. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture

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