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>   首页   >   产品   >   一抗   >   其他   >   IGFBP5 (18K8) Rabbit Monoclonal Antibody   

IGFBP5 (18K8) Rabbit Monoclonal Antibody

IGFBP5 (18K8) Rabbit Monoclonal Antibody

     
  • 1 - IGFBP5 (18K8) Rabbit Monoclonal Antibody AP93797
    Western blot analysis of extracts from Rat heart tissue using AP93797 at 1:1000.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IP
Primary Accession P24594
Reactivity Rat, Mouse
Clonality Monoclonal
Calculated MW 30298 Da
Additional Information
Gene ID 25285
Other Names Insulin-like growth factor-binding protein 5, IBP-5, IGF-binding protein 5, IGFBP-5, Igfbp5, Igfbp-5
Dilution WB~~1:1000
IP~~N/A
Storage Conditions-20℃
Protein Information
Name Igfbp5
Synonyms Igfbp-5
Function Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:23417767). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells (By similarity). Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (By similarity).
Cellular Location Secreted {ECO:0000250|UniProtKB:P24593}. Cytoplasm {ECO:0000250|UniProtKB:P24593}. Nucleus {ECO:0000250|UniProtKB:P24593}
Tissue Location Mostly in kidney.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture

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