癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GIRK2 (3K8) Rabbit Monoclonal Antibody
GIRK2 (3K8) Rabbit Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IP |
|---|---|
| Primary Accession | P48550, Unigene, 328720 |
| Reactivity | Rat, Mouse |
| Clonality | Monoclonal |
| Calculated MW | 48640 Da |
| Gene ID | 25743 |
|---|---|
| Dilution | WB~~1:1000 IP~~N/A |
| Storage Conditions | -20℃ |
| Name | Kcnj6 |
|---|---|
| Synonyms | Girk2, Kcnj7 |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Pancreatic beta cells and brain. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Enables G-protein activated inward rectifier potassium channel activity. Acts upstream of or within thyroid hormone metabolic process. Located in parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6). [provided by Alliance of Genome Resources, Apr 2022]
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