GUSB Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| IHC-P, FC, WB, E |
---|---|
Primary Accession | P08236 |
Other Accession | Q4FAT7 |
Reactivity | Human, Mouse |
Predicted | Pig |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 74732 Da |
Antigen Region | 335-362 aa |
Gene ID | 2990 |
---|---|
Other Names | Beta-glucuronidase, Beta-G1, GUSB |
Target/Specificity | This GUSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-362 amino acids from the Central region of human GUSB. |
Dilution | IHC-P~~1:100 FC~~1:10~50 WB~~1:4000 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GUSB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GUSB |
---|---|
Function | Plays an important role in the degradation of dermatan and keratan sulfates. |
Cellular Location | Lysosome. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The GUSB gene encodes beta-glucuronidase (EC 3.2.1.31), a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans (Shipley et al., 1993 [PubMed 7680524]). It is a tetrameric glycoprotein composed of identical subunits (Oshima et al., 1987 [PubMed 3468507]). The GUSB gene is mutated in mucopolysaccharidosis type VII (MPS7; MIM 253220).
REFERENCES
Tomatsu,S. Hum. Mutat. 30 (4), 511-519 (2009)
Romanowski,T. Med. Sci. Monit. 14 (7), BR147-BR152 (2008)
Gratz,M. Pharmacogenet. Genomics 15 (12), 875-881 (2005)

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