癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMC2 Rabbit Polyclonal Antibody
TMC2 Rabbit Polyclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q8TDI7 |
| Reactivity | Human, Mouse |
| Host | Polyclonal, Rabbit,IgG |
| Clonality | Polyclonal |
| Calculated MW | 102610 Da |
| Gene ID | 117532 |
|---|---|
| Other Names | Transmembrane channel-like protein 2, Transmembrane cochlear-expressed protein 2, TMC2 (HGNC:16527), C20orf145 |
| Dilution | WB~~1:1000 |
| Storage Conditions | -20℃ |
| Name | TMC2 (HGNC:16527) |
|---|---|
| Synonyms | C20orf145 |
| Function | Pore-forming subunit of the mechanotransducer (MET) non- selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:11850618). The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located (By similarity). TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:E7FFT2}; Multi-pass membrane protein. Note=Localized to the stereocilia tips of the cochlear hair cells and plasma membranes of cuticular plates. {ECO:0000250|UniProtKB:Q8R4P4} |
| Tissue Location | Detected in fetal cochlea. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015],
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