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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   RNF40 Antibody   

RNF40 Antibody

Rabbit mAb

     
  • 1 - RNF40 Antibody AP92108
    Western blot analysis of RNF40 expression in (1) HeLa cell lysate; (2) RAW264.7 cell lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IP
Primary Accession O75150
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Other Names BRE 1B; BRE1 B; BRE1B; RBP95; Rnf40; STARING;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 113678 Da
Additional Information
Dilution WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human RNF40
Description E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively).
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name RNF40
Synonyms BRE1B, KIAA0661
Function Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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