PMP70 Antibody

Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IF, FC, ICC
Primary Accession	P28288
Reactivity	Rat, Human, Mouse
Clonality	Monoclonal
Other Names	ABCD3; ABC43; PMP70; PXMP1; ZWS2;
Isotype	Rabbit IgG
Host	Rabbit
Calculated MW	75476 Da

Additional Information
Dilution	WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:100
Purification	Affinity-chromatography
Immunogen	A synthesized peptide derived from human PMP70
Description	Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
Storage Condition and Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Protein Information
Name	ABCD3 (HGNC:67)
Function	Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long- chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched- chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:24333844, PubMed:25168382, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl- CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:24333844, PubMed:25944712).
Cellular Location	Peroxisome membrane; Multi-pass membrane protein