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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   KMT1B / SUV39H2 Antibody   

KMT1B / SUV39H2 Antibody

Rabbit mAb

     
  • 1 - KMT1B / SUV39H2 Antibody AP91826
    Western blot analysis of KMT1B / SUV39H2 expression in (1) MOLT-4 cell lysate; (2) Human testis lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IP
Primary Accession Q9H5I1
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Other Names H3 K9 HMTase 2; KMT1B; Su(var)3 9 homolog 2; Suv39h2;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 46682 Da
Additional Information
Dilution WB 1:500~1:1000 IHC 1:50~1:200 IP 1:50
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human KMT1B / SUV39H2
Description Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name SUV39H2
Synonyms KMT1B
Function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
Cellular Location Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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