DCP1A Antibody

Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC, IF, FC, ICC, IHF
Primary Accession	Q9NPI6
Reactivity	Rat, Human, Mouse
Clonality	Monoclonal
Other Names	Dcp1a; HSA275986; Nbla00360; SMAD4IP1; SMIF;
Isotype	Rabbit IgG
Host	Rabbit
Calculated MW	63278 Da

Additional Information
Dilution	WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:100
Purification	Affinity-chromatography
Immunogen	A synthesized peptide derived from human DCP1A
Description	Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
Storage Condition and Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Protein Information
Name	DCP1A
Synonyms	SMIF
Function	Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271).
Cellular Location	Cytoplasm, P-body. Nucleus. Note=Co- localizes with NANOS3 in the processing bodies (By similarity) Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915) Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524) {ECO:0000250\|UniProtKB:Q91YD3, ECO:0000269\|PubMed:11836524, ECO:0000269\|PubMed:16364915}
Tissue Location	Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.